Direct Positive Chronotropic and Inotropic Effects of Ouabain in the Isolated and Blood-Perfused Canine Atrium
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چکیده
منابع مشابه
Suppression of strychnine on the chronotropic and inotropic effects in the isolated, blood-perfused canine atrium.
In the isolated, blood-perfused dog atrium, strychnine evoked dose-dependent decreases in atrial rate and contractile force, and the negative cardiac effects were not influenced by atropine. Strychnine suppressed dose-dependently the negative chronotropic and inotropic responses to intramural parasympathetic nerve stimulation, but not the response to acetylcholine. These results suggest that st...
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Ouabain-induced negative frequency-force relationship in the isolated, blood-perfused dog atrium.
Effects of ouabain, CaCl2 and verapamil on the frequency-force relationship (FFR) were investigated in the isolated, blood-perfused dog atrial muscle preparation. When ouabain (3 and 10 micrograms) or CaCl2 (0.5, 1 and 2 mg/min) was given into the sinus node artery, the contractile force of the atrial muscle, driven at a constant pacing rate of 2 Hz, increased dose-dependently. Verapamil (1 and...
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ژورنال
عنوان ژورنال: Japanese Heart Journal
سال: 1978
ISSN: 0021-4868,1348-673X
DOI: 10.1536/ihj.19.877